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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
《医学前沿（英文）》 2022年 第16卷 第1期 页码 17-24 doi: 10.1007/s11684-021-0873-2
Personalized medicine of type 2 diabetes
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《医学前沿（英文）》 2013年 第7卷 第1期 页码 1-3 doi: 10.1007/s11684-013-0241-y
Metabolomics in human type 2 diabetes research
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《医学前沿（英文）》 2013年 第7卷 第1期 页码 4-13 doi: 10.1007/s11684-013-0248-4
The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.
关键词： metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance (NMR)
The mechanisms linking adiposopathy to type 2 diabetes
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《医学前沿（英文）》 2013年 第7卷 第4期 页码 433-444 doi: 10.1007/s11684-013-0288-9
Obesity is defined as excessive accumulation of body fat in proportion to body size. When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy. Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseases. In overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type 2 diabetes. Moreover, adipokines have been shown to play important roles in the regulation of glucose homeostasis. When adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the development and progression of pancreatic β cell dysfunction and insulin resistance in peripheral tissue. The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes.
Manoj Kumar PANDA, Gopinath PILLAI, Vijay KUMAR
《能源前沿（英文）》 2013年 第7卷 第3期 页码 307-316 doi: 10.1007/s11708-013-0269-3
关键词： power system oscillations thyristor controlled series capacitor (TCSC) type-2 fuzzy logic system interval type-2 fuzzy logic controller (IT2FLC)
Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study
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《医学前沿（英文）》 2011年 第5卷 第1期 页码 94-100 doi: 10.1007/s11684-011-0116-z
Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease with high morbidity and mortality. Bone marrow is the traditional source of human MSC, but human term placenta appears to be an alternative and more readily available source. Here, the therapeutic effect of human placenta-derived MSC (PD-MSC) was studied in type 2 diabetes patients with longer duration, islet cell dysfunction, high insulin doses as well as poor glycemic control in order to evaluate the safety, efficacy and feasibility of PD-MSC treatment in type 2 diabetes (T2D). Ten patients with T2D received three intravenous infusions of PDSC, with one month interval of infusion. The total number of PDSC for each patient was (1.22–1.51) × 106/kg, with an average of 1.35 × 106/kg. All of the patients were followed up after therapy for at least 3 months. A daily mean dose of insulin used in 10 patients was decreased from 63.7?±?18.7 to 34.7?±?13.4 IU (P<0.01), and the C-peptide level was increased from 4.1?±?3.7 ng/mL to 5.6?±?3.8 ng/mL (P<0.05) respectively after therapy. In 4 of 10 responders their insulin doses reduced more than 50% after infusion. The mean levels of insulin and C-peptide at each time point in a total of 10 patients was higher after treatment (P<0.05). No fever, chills, liver damage and other side effects were reported. The renal function and cardiac function were improved after infusion. The results obtained from this pilot clinical trial indicate that transplantation of PD-MSC represents a simple, safe and effective therapeutic approach for T2D patients with islet cell dysfunction. Further large-scale, randomized and well-controlled clinical studies will be required to substantiate these observations.
A consensus model for group decision making under interval type-2 fuzzy environment
Xiao-xiong ZHANG,Bing-feng GE,Yue-jin TAN
《信息与电子工程前沿（英文）》 2016年 第17卷 第3期 页码 237-249 doi: 10.1631/FITEE.1500198
关键词： Group decision making (GDM) Interval type-2 fuzzy sets (IT2 FSs) Feedback mechanism
《医学前沿（英文）》 2022年 第16卷 第1期 页码 126-138 doi: 10.1007/s11684-021-0897-7
关键词： type 2 diabetes quality of care macrovascular complication microvascular complication treatment pattern epidemiology
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《医学前沿（英文）》 2017年 第11卷 第1期 页码 110-119 doi: 10.1007/s11684-016-0484-5
This study aims to investigate the link between glycated hemoglobin and diabetic complications with chronic periodontitis. A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according to tertiles of mean PISA (periodontal inflamed surface area) scores as low, middle and high PISA groups. Simultaneously a group of 67 periodontally healthy individuals (PH) was recruited. Periodontal examinations, including full-mouth assessment of probing depths (PPD), bleeding on probing, clinical attachment level and plaque scores were determined. Blood analyses were carried out for glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2 h post parandial glucose (PPG). Individuals in PH group had significantly better glycemic control than CP group. Upon one-way analysis of variance, subjects with increased PISA had significantly higher HbA1c levels, retinopathy and nephropathy (P<0.05). After controlling for age, gender, body mass index (BMI), socioeconomic status (SES), family history of diabetes and periodontitis, duration of diabetes, the mean PISA in mm2, PPD 4--6 mm (%) and PPD≥7 mm (%) emerged as significant predictors for elevated HbA1c in regression model (P<0.05). Logistic regression analysis revealed that PISA was associated with higher risk of having retinopathy and neuropathy (odds ratio). In our study, the association between glycemic control and diabetic complications with periodontitis was observed.
关键词： type 2 diabetes mellitus hemoglobin A glycated chronic periodontitis
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《医学前沿（英文）》 2015年 第9卷 第2期 页码 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
关键词： inflammation obesity cytokine energy expenditure insulin resistance
evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2
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《医学前沿（英文）》 2014年 第8卷 第4期 页码 471-476 doi: 10.1007/s11684-014-0365-8
This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidney injury in type 2 diabetic patients with normoalbuminuria (NAU) versus microalbuminuria (MAU) prospectively. A total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU group (n = 14) or MAU group (n= 16) according to 8 h overnight urinary albuminuria excretion rate (AER) results. A contemporary cohort of health check-up recipients were included as controls (n = 12). DWI and DTI scans were performed on bilateral kidney using SE single-shot EPI, and apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the renal parenchyma was determined from ADC and FA maps of the three groups. ADC and FA values were compared among the three groups. According to DWI with a b value of 400 s/mm2, the MAU and NAU groups showed significantly lowered mean ADC values compared with the healthy controls (P<0.01). The mean ADC in the MAU group [(2.22±0.07)×10–3 mm2/s] was slightly lower than that of the NAU group [(2.31±0.22)×10–3 mm2/s], but this difference was not statistically significant (P>0.05). The FA value in the MAU group was higher than that in the control group (0.45±0.07 vs. 0.39±0.03, P = 0.004) but did not differ from that in the NAU group (0.42±0.03) (P>0.05). ADC and FA values may be more sensitive than urine AER in reflecting early-stage kidney injury and, hence, may facilitate earlier detection and quantitative evaluation of kidney injury in T2DM patients. Combined evaluation of ADC and FA values may provide a better quantitative approach for identifying diabetic nephropathy at early disease stages.
关键词： type 2 diabetes mellitus microalbuminuria diffusion weighted imaging diffusion tensor imaging early-stage kidney injury
From gut changes to type 2 diabetes remission after gastric bypass surgeries
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《医学前沿（英文）》 2013年 第7卷 第2期 页码 191-200 doi: 10.1007/s11684-013-0258-2
Increasing evidence suggests that the gut may influence the host’s metabolism and ultimately change the outcomes of type 2 diabetes mellitus (T2DM). We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation. However, the exact changes and their relative importance in the metabolic improvements after gastric bypass surgery remain to be further clarified. Elucidating the precise metabolic mechanisms of T2DM resolution after bypass surgery will help to reveal the molecular mechanisms of pathogenesis, and facilitate the development of novel diagnoses and preventative interventions for this common disease.
关键词： gastric bypass T2DM gut
SUN Mingxiao, WANG Yao, CHI Jiamin
《医学前沿（英文）》 2008年 第2卷 第2期 页码 174-177 doi: 10.1007/s11684-008-0032-z
Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang
《医学前沿（英文）》 2020年 第14卷 第5期 页码 642-650 doi: 10.1007/s11684-019-0719-3
关键词： type 2 diabetes mellitus diabetic kidney disease miR-154-5p urinary albumin to creatinine ratio
Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological
Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao
《医学前沿（英文）》 2011年 第5卷 第3期 页码 288-293 doi: 10.1007/s11684-011-0127-9
关键词： diabetes mellitus type 2 haemorheology non-alcoholic fatty liver disease
标题 作者 时间 类型 操作
An interval type-2 fuzzy logic controller for TCSC to improve the damping of power system oscillations
Manoj Kumar PANDA, Gopinath PILLAI, Vijay KUMAR
期刊论文
Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study
null
期刊论文
A consensus model for group decision making under interval type-2 fuzzy environment
Xiao-xiong ZHANG,Bing-feng GE,Yue-jin TAN
期刊论文
Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai
期刊论文
Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population
null
期刊论文
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
null
期刊论文
evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2
null
期刊论文
Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes
SUN Mingxiao, WANG Yao, CHI Jiamin
期刊论文
Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes
Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang
期刊论文
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